منابع مشابه
Functional specialization of ribosomes?
Ribosomes are highly conserved macromolecular machines that are responsible for protein synthesis in all living organisms. Work published in the past year has shown that changes to the ribosome core can affect the mechanism of translation initiation that is favored in the cell, which potentially leads to specific changes in the relative efficiencies with which different proteins are made. Here,...
متن کاملFunctional specialization of calreticulin domains
Calreticulin is a Ca2+-binding chaperone in the endoplasmic reticulum (ER), and calreticulin gene knockout is embryonic lethal. Here, we used calreticulin-deficient mouse embryonic fibroblasts to examine the function of calreticulin as a regulator of Ca2+ homeostasis. In cells without calreticulin, the ER has a lower capacity for Ca2+ storage, although the free ER luminal Ca2+ concentration is ...
متن کاملthe effect of functional/notional approach on the proficiency level of efl learners and its evaluation through functional test
in fact, this study focused on the following questions: 1. is there any difference between the effect of functional/notional approach and the structural approaches to language teaching on the proficiency test of efl learners? 2. can a rather innovative language test referred to as "functional test" ge devised so so to measure the proficiency test of efl learners, and thus be as much reliable an...
15 صفحه اولFunctional Specialization in Proline Biosynthesis of Melanoma
Proline metabolism is linked to hyperprolinemia, schizophrenia, cutis laxa, and cancer. In the latter case, tumor cells tend to rely on proline biosynthesis rather than salvage. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). Here, the role of three isozymic versio...
متن کاملNarrowing-driven Specialization of Functional Logic Programs
Languages that integrate functional and logic programming with a complete operational semantics are based on narrowing, a unification-based goal-solving mechanism which subsumes the reduction principle of functional languages and the resolution principle of logic languages. Formal methods of transformation of functional logic programs can be based on this wellestablished operational semantics. ...
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ژورنال
عنوان ژورنال: Trends in Biochemical Sciences
سال: 2011
ISSN: 0968-0004
DOI: 10.1016/j.tibs.2010.12.002